Transforming Dental Treatment
Versatile Applications
Effective across a wide range of dental procedures
Periodontal Regeneration
Periosomes Repair Damaged Tissue
3D exosomes regenerate damaged periodontal tissues, including cementum, periodontal ligament, and alveolar bone.
Anti-Inflammatory Effects
Restores balance between pro-inflammatory Th17 cells and anti-inflammatory Tregs via enriched miR-1246, reducing inflammation and halting bone loss.
Clinical Impact
Reduce pocket depths and stabilize loose teeth.
Deliver Techniques
3D Exosomes can be applied via local injections or combined with scaffolds for sustained release at treatment sites.
Intraoral Wound Healing
Accelerated Recovery
Promotes fibroblast migration, angiogenesis, and collagen synthesis for faster healing after surgical or traumatic injuries.
Scar Reduction
Modulates inflammation and supports tissue remodeling for improved esthetic outcomes.
Advanced Delivery Systems
Hydrogels loaded with 3D exosomes ensure prolonged therapeutic effects in the oral cavity.
Minimize Scarring
Optimize ECM remodeling for esthetic outcomes in post-surgical or traumatic wounds.
Alveolar Ridge Preservation
Preserve Bone Volume
3D exosome-loaded scaffolds (e.g., collagen/HA composites, PLA/PLGA membranes) reduce post-extraction resorption by 40–60%.
Prepare for Implants
Maintain ridge dimensions for predictable prosthetic outcomes.
Improved Graft Integration
3D exosome-loaded scaffolds reduce bone resorption and promote new bone formation after tooth extraction or grafting.
Custom Solutions
Compatible with cutting-edge materials like polycaprolactone-tricalcium phosphate (PCL-TCP) for tailored bone regeneration.
Alveolar Bone Grafting
Enhance Osteogenesis
SHED-derived 3D exosomes activate Wnt/β-catenin pathways in PDLSCs, improving graft integration and bone density.
Improved Graft Integration
3D exosomes enhance bone regeneration and integration with native tissues.
Case Use
Ideal for cleft palate repairs or trauma-induced defects.
Implant Success
Boost Osseointegration
3D exosome primed implant surfaces to accelerate bone-to-implant contact (BIC) by 30–50% ensuring long-term stability.
Stability and Longevity
Enhanced osseointegration improves implant stability and longevity.
Prevent Peri-Implantitis
Anti-inflammatory 3D exosomes reduce biofilm-induced inflammation.
Mechanical Strength
Boosts trabecular bone density around implants for superior load-bearing capacity.
Targeted Therapy
Fusion peptides anchor 3D exosomes directly to implant surfaces for precise therapeutic delivery.
Dental Pulp Regeneration
Revitalize Pulp
DPSC-derived 3D exosomes.
Cell Homing Approach
3D exosomes recruit stem cells from the apical papilla (SCAPs) to regenerate pulp-like tissue containing odontoblasts and blood vessels.
Minimally Invasive Therapy
Eliminates the need for cell transplantation by using 3D exosome-loaded scaffolds within treated root canals.
Clinical Potential
Offers a groundbreaking alternative for managing pulp necrosis or irreversible pulpitis while preserving natural tooth structure.
How to Integrate 3D Exosomes into Your Practice
1 Localized Delivery
- Injectables: Administer 3D exosome solutions directly into periodontal pockets or extraction sites.
- Paste Formulations: Apply topical 3D exosome paste for mucosal injuries or dry socket management.
2 Scaffold-Based Therapy
- Sustained Release Matrices: Combine 3D exosomes with collagen, hydroxyapatite, or PLA/PLGA scaffolds for ridge preservation or grafting.
- Customization: Tailor scaffold porosity and 3D exosome release kinetics to patient needs.
3 Synergy With Existing Protocols
- Guided Bone Regeneration (GBR): Enhance membrane efficacy with 3D exosome coatings.
- PRF Combinations: In extraordinary cases pair 3D exosomes with platelet-rich fibrin for synergistic healing.
Ready to Explore 3D Exosome Technology?
Contact our team of experts to discuss how our solutions can benefit your research or clinical applications.